The U.S. military has launched airstrikes against two terrorist groups in Syria, using manned aircraft, drones and Tomahawk cruise missiles fired by Navy warships, according to U.S. Central Command.

Aircraft from the Air Force, Navy and Marine Corps took part in the airstrikes, according to a news release Wednesday from CENTCOM. All aircraft returned safely. The destroyer Arleigh Burke and cruiser Philippine Sea also fired a total of 47 Tomahawk cruise missiles at targets.

The Wall Street Journal is reporting that the F-22 has made its combat debut by participating in the airstrikes in Syria. The CENTCOM news release did not specify what type of aircraft conducted the airstrikes, describing them as "a mix of fighter, bomber and remotely piloted aircraft."

Bahrain, Jordan, Qatar and the United Arab Emirates also took part in 14 airstrikes overnight against the Islamic State, which is also referred to as the Islamic State of Iraq and the Levant, according to the CENTCOM news release.

"The strikes destroyed or damaged multiple ISIL targets in the vicinity of Ar Raqqah, Dayr az Zawr, Al Hasakah, and Abu Kamal and included ISIL fighters, training compounds, headquarters and command and control facilities, storage facilities, a finance center, supply trucks and armed vehicles," Wednesday's news release says.

Separately, the U.S. targeted another group in Syria to thwart an "imminent attack against the United States and Western interests," the news release says. The Khorasan Group, which is made up of "seasoned al-Qaida veterans," has established a safe haven in Syria to build bombs and recruit westerners. Those airstrikes were carried out exclusively by the U.S.

"In total, U.S. Central Command conducted eight strikes against Khorasan Group targets west of Aleppo to include training camps, an explosives and munitions production facility, a communication building and command and control facilities," the news release says.

The allied strikes in Syria were not invited by the government of Bashar Assad, although the U.S. advised Syria's United Nations envoy of the upcoming attacks, according to Syria's state news agency.

Assad, is waging a brutal civil war against opponents of his regime, including Islamic State militants. It's unclear how Assad will react to the U.S.-led attacks. His military possesses sophisticated anti-aircraft missiles, although most of them are near the capital of Damascus and near the border with Israel.

About two thirds of the estimated 30,000 Islamic State fighters are based in Syria. The remainder have captured large parts of northern Iraq, although their momentum has been blunted there by U.S. fighter, bomber and drone aircraft. Last week, French warplanes launched attacks on Islamic State targets in Iraq for the first time.

For the last several weeks, U.S. spy planes have been flying over Syria collecting intelligence on potential Islamic State targets.

Meanwhile, the U.S. carried out four more airstrikes against Islamic State targets in Iraq, bringing the total number of airstrikes launched in Iraq since August to 194, the CENTCOM news release says.

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USA Today contributed to this report.

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