The military outpost was run for years by U.S. troops as part of the war against the Islamic State group.
The new round of strikes follows the deadly December ambush that killed two U.S. soldiers and one American civilian interpreter.
The decision follows Syrian government forces taking control of camps with IS detainees after the U.S.-backed Syrian Democratic Forces withdrew.
The move brings to a close more than two decades of American military presence in the western part of the country.
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